[Dynamics of indices of peripheral circulation as one of the prognostic criteria in acute myocardial infarction]. / Dinamika pokazatelei perifericheskogo krovotoka kak odin iz prognosticheskikh kriteriev pri ostrom infarkte miokarda.

The results of our investigations demonstrate that significant differences exist in peripheral hemodynamics of patients with severe and more favourable course of acute myocardial infarction. This can be explained by different types of hemodynamics. Thus, such parameters as arterial inflow and venous outflow can serve prognostic factors of acute myocardial infarction.

[On possible prognostic values of anti-endotoxin immunological parameters in acute myocardial infarction]. / O vozmozhnom prognosticheskom znachenii pokazatelei anti-éndotoksinovogo immuniteta pri ostrom infarkte miokarda.

Endotoxin is a biologically active substance that has a lipopolysaccharide structure. It is found in the cell walls of microorganisms, principally gram-negative bacteria. By contacting with the cell, endotoxin enhances immunity. The findings suggest that acute myocardial infarction (AMI) occurs due to low immunity that remains the same at week 3 of the disease, thus the levels of antiendotoxin agents may be used in predicting AMI.

[Acute respiratory distress syndrome in endotoxic shock]. / Ostryi respiratornyi distress-sindrom pri éndotoksinovom shoke.

Large amounts of lipopolysaccharides released in blood after death of Gram-negative bacteria are responsible for endotoxinemia and endotoxic shock. Endotoxin is eliminated from the body via different routes including the lungs. One of the mechanisms of lipopolysaccharides transport to the lungs, which respond with acute distress syndrome, is their transfer by polymorphonuclear leukocytes.

[Central hemodynamics of patients during an attack of bronchial asthma]. / Tsentral'naia genodinamika u bol'nykh vo vremia pristupa bronkhial'noi astmy.

The authors presented the results of a combined study of 100 patients with infectious-allergic bronchial asthma. During and after attacks of asphyxia parameters of central hemodynamics and pressure in the lesser circulation system were defined. The patients were divided into 3 groups with relation to cardiac output values. An increase in cardiac output and pressure elevation in the right ventricle were noted in the 1st group, the values of pressure of pulmonary artery obstruction slightly raised. The absence of a marked increase in cardiac output was observed in the 2nd group, however pressure in the arterial system of the lesser circulation increased in the period of asphyxia. A decrease in cardiac output and an increase in pressure in the system of the pulmonary artery were noted in the patients of the 3rd group during asthmatic attacks. Such changes in the hemodynamics of the patients with bronchial asthma during attacks of asphyxia led to an idea of a possible favorable reaction of the cardiovascular system in the 1st group, maximum effort of compensatory capabilities in the 2nd group and depletion of reserve function of the cardiovascular system in the 3rd group. An elevation of pressure of pulmonary artery obstruction in the patients of the 2nd and 3rd groups confirmed a possibility of development not only of right but also left ventricular circulatory insufficiency during an attack of bronchial asthma.

[Physical work capacity prognosis of hypertensive patients]. / Prognozirovanie fizicheskoi rabotosposobnosti u bol'nykh gipertonicheskoi bolezn'iu.

From the results of the examination of 176 patients with hypertensive disease the authors compared 49 signs, including sex, age, the findings of medical history, inspection, X-ray, ECG and consultations of an ophthalmologist with the power of physical exertion on a bicycle ergometer. Fifteen signs with a marked correlative connection with the power of exertion (r greater than 0.5) were distinguished. Systolic arterial pressure (170 mm Hg and more), circulatory insufficiency, concomitant ischemic heart disease, atherosclerosis of the peripheral arteries and hypokinetic type of circulation proved to be the most important factors limiting the physical working capacity of patients with hypertensive disease. A table for prognosticating the working capacity was compiled.

[Effect of emotional stress on the contractile function of human heart (according to the echocardiographic data)]. / Vliianie émotsional'nogo napriazheniia na sokratitel'nuiu funktsiiu serdtsa cheloveka (po dannym ékhokardiografii).

Cardiac function was studied by echocardiography in 12 healthy sixth-year students at mid-semester, immediately before taking an exam and 30 minutes after it. It was found that the emotional stress experienced prior to the exam is attended with an increase in cardiac output by one and a half times and external work by two. This increase of the pump cardiac function is ensured without any essential increase in the diastolic dimensions of the left cardiac ventricle at the expense of fuller blood ejection from the left ventricle and decrease of its residual systolic volume. Since the students had taken more than 50 exams in the past and were adapted to the pre-examination situation, the circulatory changes revealed may be regarded as adaptive providing for the rich flow of blood to the brain.